acuA [2017-8-11 16:0:3]

protein acetylase for the control of AcsA activity

Locus: BSU29690

Isoelectric point: 5.03

Molecular weight: 24.18 kDa

Protein length: 210 aa

Gene length: 630 bp

Function: control of AcsA activity

Product: Gcn5-related N-acetyltransferase

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of organic acids
• Metabolism → Lipid metabolism → Utilization of lipids → Utilization of fatty acids
• Information processing → Protein synthesis, modification and degradation → Protein modification → Protein acetylases/ deacetylases

Gene

Coordinates: 3,040,092 → 3,040,724

The protein

Catalyzed reaction/ biological activity

• acetylates (and thereby inactivates) AcsA on Lys-549 PubMed PubMed

Protein family

• acetyltransferase family (according to Swiss-Prot) Gcn5-relatedN-acetyltransferase PubMed

Expression and Regulation

Operons

• Genes: acuA-acuB-acuC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon

  Regulation

  • repressed by glucose (3.4-fold) (CcpA) PubMed

  Additional information

  • the mRNA is quite stable (half-life 5 min) PubMed

Biological materials

Mutant

• GP1211 (acuA::kan), available in Jörg Stülke's lab
• GP1255 (acuA::kan yjcK::cat ynaD::spec yoaA::tet), available in Jörg Stülke's lab

References

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